Windows Vista is the first end-user version of Windows

Windows NT included support for several different platforms before the x86-based personal computer became dominant in the professional world. Versions of NT from 3.1 to 4.0 variously supported PowerPC, DEC Alpha and MIPS R4000, some of which were 64-bit processors, although the operating system treated them as 32-bit processors.

With the introduction of the Intel Itanium architecture, which is referred to as IA-64, Microsoft released new versions of Windows to support it. Itanium versions of Windows XP and Windows Server 2003 were released at the same time as their mainstream x86 (32-bit) counterparts. On April 25, 2005, Microsoft released Windows XP Professional x64 Edition and x64 versions of Windows Server 2003 to support the x86-64 (or x64 in Microsoft terminology) architecture. Microsoft dropped support for the Itanium version of Windows XP in 2005. Windows Vista is the first end-user version of Windows that Microsoft has released simultaneously in x86 and x64 editions. Windows Vista does not support the Itanium architecture. The modern 64-bit Windows family comprises AMD64/Intel64 versions of Windows Vista, and Windows Server 2008, in both Itanium and x64 editions. Windows Server 2008 R2 drops the 32-bit version, although Windows 7 does not.